The investigation and handling results of medical research integrity cases recently publicly notified by medical institutions affiliated to some health administrative departments are reproduced as follows:
1. The paper "Kaempferol repressions but increases apoptosis and autophagy by up-regulating microRNA-340 in human lung cancer cells" published by Cecilia Han, Dalian Central Hospital, Liaoning Province, was the first author. After investigation, it was found that there was paper buying and selling behavior, and all the authors did not get informed consent according to the standard procedures before submission. Dalian Central Hospital dealt with Cecilia Han as follows: giving administrative warning; Recorded in the scientific research integrity system management for five years; Cancel the qualifications of scientific research project declaration, science and technology award, outstanding talent plan, outstanding party member, declaration of various bases, job promotion, professional title promotion and appointment within 5 years; It is suggested that Dalian Medical University cancel the qualification of master tutor and can not apply again within five years; Take back the excellent thesis award awarded by the hospital; Conduct a conversation on scientific research integrity and write a commitment letter on scientific research integrity.
(notification link: https://www.dlzxy.com/pages/sys/web/details/articledetails.html? oneId=19&twoId=5&articleaId=794?）
Second, Gao Wei, the first author and correspondent of Dalian Central Hospital, Liaoning Province, published the paper "Ailanthon exerts anticancer effect by up-regulating mir-148a expression in MDA-MB-231 breath cancer cells, migration and invasion". After investigation, it was found that there was paper trading. Dalian Central Hospital dealt with Gao Wei as follows: giving warning within the party; Recorded in the scientific research integrity system management for five years; Cancel the qualifications of scientific research project declaration, science and technology award, outstanding talent plan, outstanding party member, declaration of various bases, job promotion, professional title promotion and appointment within 5 years; Take back the excellent thesis award awarded by the hospital; Conduct a conversation on scientific research integrity and write a commitment letter on scientific research integrity.
(notification link: https://www.dlzxy.com/pages/sys/web/details/articledetails.html? oneId=19&twoId=5&articleaId=793?）
Third, the paper "Long Non-coding RNA tug1 alleviates LPS-induced infection of PC-12 cells by down-regulating microRNA-127" published by Cao Jin, the correspondent of the Sixth Hospital of Ningbo, Zhejiang Province, as the first author, was entrusted by Zheng Huajiang to write it on behalf of a third party. The correspondent Cao Jin was unaware of the writing and contribution of the paper, but did not know it after publication. The Sixth Hospital of Ningbo dealt with the relevant responsible personnel:
1. Suspend the promotion of Zheng Huajiang’s professional and technical position for five years, cancel his qualification for applying for science and technology projects (special projects and funds) and science and technology awards for five years, cancel his qualification as an expert in papers, projects and science and technology awards for five years, give him an admonishing talk on scientific research integrity, give him an administrative warning, and deduct a three-month bonus;
2. Cancel Cao Jin’s qualification to apply for science and technology projects (special projects and funds) and science and technology awards for one year.
(Notification link: http://www.nbdlyy.com/art/2021/6/15/art_1740_632390.html)
4. The paper "Physcion 8-O-β-glucopyranoside exhibits anti-tumor activity against non-small cell lung cancer by targeting PPAR γ" published in 2019 by Zhou Jiafeng, the correspondent of Lishui Central Hospital, Zhejiang Province, with Du Youyi as the first author. After investigation, the paper involved academic misconduct such as forging and tampering with research data and charts. Lishui Central Hospital gives the following treatment to relevant responsible personnel:
1. Admonish Zhou Jiafeng and Du Youyi, cancel the qualification of applying for or applying for science and technology projects (special projects, funds, etc.), science and technology awards and scientific and technological talents within five years, and postpone the promotion to professional and technical positions for two years;
2. Criticize and educate other authors, such as Li Yuan, Sun Lei, Lv Zhuqing and Sun Debin, and cancel the application or declaration of science and technology projects (special projects, funds, etc.), science and technology awards and titles of scientific and technological talents within one year, and then they shall not be promoted to professional and technical positions.
(Notification link: http://www.lshospital.zj.cn/Article/HTML/13081.html)
5. The paper "Mir-203 Regulates DJ-1 Expression and Affects Proliferation" published by Dong Zhihui as the correspondent and Du Shilin as the first author, Apocalypse and DDP Resistance of Pancreative Cancer Cells ",after investigation, Du Shilin personally wrote and contributed on his behalf through a third-party organization, and did not inform all the authors before submitting the manuscript, which led to academic misconduct of writing on his behalf and improperly signing. Luoyang Central Hospital has made the following treatment for relevant responsible personnel:
1. Du Shilin, the first author, was admonished, given a warning, and informed criticism was ordered to make an in-depth inspection. The declaration of financial support for scientific research projects was suspended for 5 years, the declaration of deputy senior titles was suspended for 5 years, and the personal evaluation qualification was cancelled for 5 years;
2. Dong Zhihui, the author of the communication, was admonished and warned, and informed criticism was ordered to make an in-depth inspection;
3. Give admonishing talks to other authors Xu Lingyan, Gao Peng, Liu Qingsheng, Lu Fangfang, Mo Zheheng, Fan Zhenzhen and Cheng Xinling on scientific research integrity;
4. Withdraw the manuscript of the paper and prohibit all related applications of the paper.
(Notification link: http://www.lyszxyy.com/study_kydt/2021/yb86ojev.html)
6. He Shehong, Central Hospital of Luoyang, Henan Province, is the author of communication. Xue Congling’s paper "Physcion 8-0-b-glucopyranoside exhibits anti-growth and anti-meta-static activities in ovarian cancer by down regulating Mir-25" published for the first author was investigated, which was written by Xue Congling personally through a third-party organization and submitted on his behalf, and all the authors were not informed before submission, involving academic misconduct of writing on behalf of others and improper signature. Luoyang Central Hospital has made the following treatment for relevant responsible personnel:
1. Xue Congling, the first author, was admonished and warned, and informed criticism was given an in-depth examination. He was ordered to suspend the application for financially supported scientific research projects for five years, suspend the application for doctoral and master’s degree tutors for five years, postpone the employment of deputy senior titles for five years, collect the reimbursement of layout fees and reward income, and cancel the personal evaluation qualification for five years;
2. He Shehong, the author of the communication, was admonished, warned and punished, and informed criticism was ordered to make an in-depth inspection;
3. Give admonishing talks to other authors Liu Honggai, Li Bingyi and Yue Qingfen on scientific research integrity;
4. Withdraw the manuscript of the paper and prohibit all related applications of the paper.
(Notification link: http://www.lyszxyy.com/study_kydt/2021/Pe9QpJeL.html)
7. The paper "Alpinum Soflavone Causes DNA Damage in Colored Cancer Cells via Blocking DNA Repair Mediated by RAD 51" published by Li Dong, the correspondent and the first author of Puyang Oilfield General Hospital, Henan Province, was found to contain trading data and improper signature. Puyang Oilfield General Hospital withdrew the manuscript of this paper, and made the following treatment for the participants:
1. Give Li Dong (the first author and correspondent) a warning, give a admonishing talk on scientific research, and cancel the qualification of applying for scientific research projects, scientific and technological awards, titles of scientific and technological talents, promotion of professional and technical positions and evaluation of units and individuals within five years in informed criticism;
2. Give admonishing talks on scientific research integrity to Li Gen District (three works), Meng Yan (four works), Jin Yanghong (five works), Shang Shuang (six works) and Li Yanjie (seven works), and cancel the five-year application or declaration of science and technology plan projects (special projects, funds, etc.), science and technology awards, titles of scientific and technological talents, promotion of professional and technical positions and first-class qualifications of units and individuals;
3, cancel Li Xiaoyan (two) 1 year application or declaration of science and technology projects (special projects, funds, etc.), science and technology awards, the title of scientific and technological personnel, professional and technical positions promotion and unit personal evaluation and other qualifications.
(Notification link: https://www.pysytzyy.com/news_view.asp? id=2130?）
8. Yan Xuetao, the Maternal and Child Health Hospital of Baoan District, Shenzhen City, Guangdong Province, is the author of the communication. Chen Hu’s paper "LNC RNA malat1 regulations separation-induced cardiac infection and dysfunction via interaction with Mir-125b and P38 MAPK/NF κ B" published for the first author, after investigation, was entrusted to a third party for experimental operation, and there were traces of modification in the pictures in the paper, which involved academic misconduct of picture forgery. The Maternal and Child Health Hospital of Baoan District, Shenzhen has made the following treatment for the relevant responsible personnel:
1, the author of the paper for scientific research integrity admonishing conversation, request to withdraw the paper, to recover the reward;
2. Chen Hu, the first author of the paper, and Yan Xuetao, the author of the newsletter, were suspended from applying for the qualification of scientific research projects at all levels for 5 years, and the senior title of Chen Hu, the first author, was cancelled, and Yan Xuetao, the author of the newsletter, was suspended from enrolling postgraduate qualifications for 5 years;
3. The authors of the paper, Wang Xiaoyun, Cheng Xiaoli and Zheng Wenzhong, were suspended from applying for the qualification of scientific research projects at all levels for one year.
(notification link: http://www.bawjxt.net/fy/kxyjjpx/yxyj/202107/t20210706 _ 5735896.html)
9. Hong Chengying, People’s Hospital of Shenzhen City, Guangdong Province, is the author of the communication. Liu Xiaodi’s paper "Down regulation of LNC RNA tug1 contributions to the development of separatism-associated acute kidney involvement via regulating mir-142-3p/ Sir tuin 1 axis and modulating NF ‐ κ B pathway ",after investigation, was operated by a third-party organization, and there were many similarities in the pictures in this paper, which involved academic misconduct such as picture fraud. Shenzhen People’s Hospital has made the following treatment for relevant responsible personnel:
1. Talk to communication author Hong Chengying about the integrity of scientific research, make public informed criticism in the hospital, and cancel the qualifications of applying for or reporting scientific research projects (special projects, funds, etc.), scientific and technological awards, titles of scientific and technological talents and promotion of professional and technical positions within three years;
2. The first author Liu Xiaodi and other secondary responsible authors, such as Wu Shipin, Yang Zhi, Cao Lin, Song Tongwei and Angelababy, were admonished for scientific research integrity and informed criticism was made public in the hospital.
(Notification link: https://www.szhospital.com/? fid=A008&part=localfrm&pk=10315?）
X. The paper "Propofol Weakens Hypoxia-Aroused Apology and Autopharmy via Elevating MicroRNA-137 in Neurogenes" published by Zeng Yuan, the Third Hospital of Xi ‘an, Shaanxi Province, as the correspondent and Chang Jianhua, the People’s Hospital of Shaanxi Province as the first author, was commissioned by a third party to write and contribute after investigation. The Third Hospital of Xi ‘an dealt with Zeng Yuan, the responsible person, as follows: given a warning; Conduct a conversation on scientific research integrity; Submit personal written examination and conduct informed criticism; Delaying the declaration of professional and technical post promotion qualification for 5 years; Stop applying for all kinds of scientific research funds for 5 years; Stop using the scientific research platform in the hospital for 5 years; Deduct personal performance for one month; Withdraw the manuscript. The People’s Hospital of Shaanxi Province dealt with Chang Jianhua, the responsible person, as follows: he ordered the paper to be withdrawn and talked about scientific integrity; Give a warning and inform the whole hospital; Cancel the qualification for promotion within 6 years; Stop recommending all kinds of talents for 2 years.
(Notification link: http://www.xa3yuan.com/detaile/21061114APvEb)
XI. The paper "MicroRNA-1247 inhibitions lipolysaccharides-induced acute cancer in A549 cells via targeting CCCEMOKINE Ligand 16" published by Guo Jinjing of Weinan Maternal and Child Health Hospital, Shaanxi Province as the correspondent and the first author, was found by investigation that Guo Jinjing entrusted a third party to write for him, and other authors Cheng Ying improperly signed it. Weinan Maternal and Child Health Hospital has made the following treatments for the relevant responsible persons:
1. Guo Jinjing, the author of the communication and the first author, was ordered to withdraw the manuscript, talked about scientific integrity and admonished, given administrative warning and informed criticism in the hospital, canceled the qualification of promotion of professional titles within 6 years, and applied for or declared the title of scientific and technological plan projects (special projects, funds, etc.), scientific and technological awards and scientific and technological talents;
2. Cheng Ying, another author, was admonished for scientific research integrity. informed criticism in the hospital was disqualified from being promoted to a professional title within one year.
(Notification link: http://www.wnfybj.com/index.php? m=content&c=index&a=show&catid=95&id=3503?）
12. The paper "Mir-155 Regulation Lymphoma Cell Proliferation and AposisThroughargetingsoCS3/JAK-STAT3 Signaling Pathway" published by Sun Xiaochen, People’s Hospital of Yan ‘an City, Shaanxi Province, with Li Xiaodong as the first author, was found to be written by Li Xiaodong on behalf of a third party and improperly signed by the correspondent and other authors. Yan’ an People’s Hospital makes the following treatment for the relevant responsible persons:
1. Li Xiaodong, the first author, took the main responsibility, admonished him for scientific research integrity, gave him an administrative warning, and informed criticism of the whole hospital, revoked the use of the award-winning items and titles of this paper, recovered the bonus, banned the declaration of various national, provincial and municipal projects, the declaration of awards and the promotion of titles within six years, and ordered him to withdraw the manuscript;
2. Sun Xiaochen, the author of the communication, improperly signed his name, admonished him for scientific research integrity, gave him a warning in the hospital and informed criticism in the whole hospital, and banned him from applying for various national, provincial and municipal projects, rewarding him, and promoting his professional title within three years;
3. Other authors, Li Xinmei and Gu Jiawei, improperly signed their names, admonished and talked about scientific integrity, and informed criticism of the whole hospital was forbidden to declare national, provincial and municipal projects, reward declarations and promotion titles within one year. ?
(Notification link: http://www.yasrmyy.cn/8/39931/content.aspx)